The gene areg encodes amphiregulin, an epidermal growth factor (EGF)-family ligand and signaling molecule that functions as a mitogen by binding and activating the egf receptor. It is synthesized as a ...[+]

The gene areg encodes amphiregulin, an epidermal growth factor (EGF)-family ligand and signaling molecule that functions as a mitogen by binding and activating the egf receptor. It is synthesized as a transmembrane precursor protein that is proteolytically cleaved to release the soluble, secreted growth factor. Its expression is detected in the epidermis and neural tissue during development where it promotes cell proliferation. [-]

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