The hes3 gene encodes a bHLH transcription factor expressed in the neural plate border and later in cranial ganglia precursors and dorsal root ganglia. Hes3 protein functions as a transcriptional repre...[+]

The hes3 gene encodes a bHLH transcription factor expressed in the neural plate border and later in cranial ganglia precursors and dorsal root ganglia. Hes3 protein functions as a transcriptional repressor involved in maintaining progenitor cells within the nervous system by inhibiting neuronal differentiation. Expression is also observed in the otic vesicle, branchial arches, and olfactory placode. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD