The apela gene encodes a short signaling peptide that is secreted. In early development, apela mRNA is expressed in the dorsal marginal zone and later in the notochord and hatching gland. The apela pro...[+]

The apela gene encodes a short signaling peptide that is secreted. In early development, apela mRNA is expressed in the dorsal marginal zone and later in the notochord and hatching gland. The apela protein functions as an endogenous ligand for the gpr113/elp receptor. It activates erk signaling and is involved in regulating gastrulation movements, contributing to proper axial mesendoderm formation. [-]

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