The gene pirt encodes a proton-sensing g protein-coupled receptor expressed in mRNA within dorsal root ganglia and spinal cord neurons. The protein is localized to the plasma membrane where it function...[+]

The gene pirt encodes a proton-sensing g protein-coupled receptor expressed in mRNA within dorsal root ganglia and spinal cord neurons. The protein is localized to the plasma membrane where it functions as a sensory neuron-specific modulator that can inhibit transient receptor potential vanilloid 1 (TRPV1) channel activity and impact thermal sensitivity. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD