The tmem108 gene encodes a transmembrane protein localized to the cell membrane. It functions as a positive regulator of Wnt/β-catenin signaling during neural crest specification and is implicated in c...[+]

The tmem108 gene encodes a transmembrane protein localized to the cell membrane. It functions as a positive regulator of Wnt/β-catenin signaling during neural crest specification and is implicated in cranial ganglia, eye, and craniofacial development. Expression analysis reveals its presence in the anterior neural plate border, migrating cranial neural crest cells, branchial arches, otic vesicle, and retina. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD