The bmp5 gene encodes a secreted ligand of the transforming growth factor-beta superfamily and bone morphogenetic protein subfamily, acting as a signaling molecule. In embryos, its expression is detect...[+]

The bmp5 gene encodes a secreted ligand of the transforming growth factor-beta superfamily and bone morphogenetic protein subfamily, acting as a signaling molecule. In embryos, its expression is detected in the ventral mesoderm during gastrulation and neurula stages, later localizing to specific regions including the branchial arches, otic vesicle, and developing cartilage elements. The protein functions in dorsoventral patterning of the early embryo and is involved in the development of the cranial skeleton and the ear. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD