The hras gene encodes a small gtpase protein that functions as a molecular switch in intracellular signal transduction. it is involved in the mapk cascade, regulating cell proliferation, differentiatio...[+]

The hras gene encodes a small gtpase protein that functions as a molecular switch in intracellular signal transduction. it is involved in the mapk cascade, regulating cell proliferation, differentiation, and migration during development. its activity is modulated by cycling between gdp-bound inactive and gtp-bound active states. the protein localizes to the plasma membrane and cytoplasm. documented roles include involvement in neural crest formation, ectoderm patterning, and craniofacial development. [-]

             urinary bladder cancer
             follicular thyroid carcinoma
             epidermal nevus
             linear nevus sebaceous syndrome
             large congenital melanocytic nevus

          COSTELLO SYNDROME; CSTLO
          THYROID CANCER, NONMEDULLARY, 2; NMTC2
          NEVUS, EPIDERMAL
          MELANOCYTIC NEVUS SYNDROME, CONGENITAL; CMNS
          SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME; SFM

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD