tdgf1.3 encodes a nodal co-receptor protein that is membrane-bound via a glycosylphosphatidylinositol (GPI) anchor, localizing it to the cell surface and extracellular space. It functions in mesendoder...[+]

tdgf1.3 encodes a nodal co-receptor protein that is membrane-bound via a glycosylphosphatidylinositol (GPI) anchor, localizing it to the cell surface and extracellular space. It functions in mesendoderm induction and left-right axis patterning during early development. Expression is found in the dorsal mesoderm, specifically the organizer region, during blastula and gastrula stages. The protein facilitates nodal signaling by binding to nodal ligands and type i activin-like kinase receptors. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD