The wif1 gene in Xenopus laevis and Xenopus tropicalis encodes a secreted Wnt inhibitory factor that functions as a Wnt signaling antagonist, acting as a secreted signaling molecule localized extracell...[+]

The wif1 gene in Xenopus laevis and Xenopus tropicalis encodes a secreted Wnt inhibitory factor that functions as a Wnt signaling antagonist, acting as a secreted signaling molecule localized extracellularly. It is involved in embryonic development, with expression in neural crest cells and other tissues, where it inhibits Wnt signaling pathways during embryogenesis. The protein functions as a Wnt antagonist, binding to Wnt proteins to modulate Wnt signaling pathways. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD