Based on Xenbase, the gene tom1l1 in Xenopus laevis and Xenopus tropicalis encodes a protein involved in endosomal protein sorting and multivesicular body formation. It functions within the ESCRT pathw...[+]

Based on Xenbase, the gene tom1l1 in Xenopus laevis and Xenopus tropicalis encodes a protein involved in endosomal protein sorting and multivesicular body formation. It functions within the ESCRT pathway, facilitating the sorting and degradation of ubiquitinated membrane proteins. The protein localizes to endosomes and is implicated in cytokine receptor sorting and degradation processes. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD