The pdyn gene encodes a preproprotein that is cleaved to produce opioid neuropeptides including dynorphins, which act as endogenous ligands for kappa-opioid receptors. these peptides function in nocice...[+]

The pdyn gene encodes a preproprotein that is cleaved to produce opioid neuropeptides including dynorphins, which act as endogenous ligands for kappa-opioid receptors. these peptides function in nociception, appetite regulation, and stress response. the protein is a secreted signaling molecule. expression is documented in the brain, spinal cord, pituitary gland, and skin. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD