The lsm14b gene encodes an RNA-binding protein involved in germ plasm formation and is a core component of processing bodies (P-bodies). The protein localizes to P-granules in the germline and to the o...[+]

The lsm14b gene encodes an RNA-binding protein involved in germ plasm formation and is a core component of processing bodies (P-bodies). The protein localizes to P-granules in the germline and to the outer mitochondrial membrane in oocytes, where it functions in the regulation of maternal mRNA storage, translation, and decay. It plays a role in oocyte maturation through interactions with mRNA and is required for proper assembly of ribonucleoprotein complexes involved in primordial germ cell specification. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD