dchs2 encodes a transmembrane receptor protein that functions as a signaling molecule within the Hippo pathway and is involved in planar cell polarity processes affecting convergent extension movements...[+]

dchs2 encodes a transmembrane receptor protein that functions as a signaling molecule within the Hippo pathway and is involved in planar cell polarity processes affecting convergent extension movements during gastrulation and neurulation. The dchs2 protein localizes to the plasma membrane and mediates cell adhesion, influencing tissue morphogenesis and patterning; its expression is documented in the developing pronephros, brain, eye, branchial arches, and somites. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD