The btg4 protein acts as an adapter for the CCR4-NOT deadenylase complex, facilitating mRNA decay by recruiting the complex to target mRNAs for deadenylation during oocyte maturation and early embryoge...[+]

The btg4 protein acts as an adapter for the CCR4-NOT deadenylase complex, facilitating mRNA decay by recruiting the complex to target mRNAs for deadenylation during oocyte maturation and early embryogenesis. It is a cytoplasmic protein that localizes to P-bodies and is also found in the nucleus of some cells; its expression is maternal and zygotic, with transcripts detected in the ovary, testis, oocytes, and throughout early embryonic development including the blastula, gastrula, neurula, and tailbud stages. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD