The gene tnfsf10 encodes a type ii transmembrane protein and tumor necrosis factor ligand, which can be proteolytically cleaved to form a soluble cytokine. This protein functions as a death receptor ag...[+]

The gene tnfsf10 encodes a type ii transmembrane protein and tumor necrosis factor ligand, which can be proteolytically cleaved to form a soluble cytokine. This protein functions as a death receptor agonist that induces apoptosis through caspase activation in susceptible cells. It is involved in immune response regulation and plays a role in embryonic development, particularly in the cranial neural crest where it influences cell migration and craniofacial morphogenesis. Expression is detected in the developing brain, gills, and branchial arches. The protein can be membrane-bound or secreted following cleavage. [-]

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