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Summary Expression Phenotypes Gene Literature (4) GO Terms (12) Nucleotides (158) Proteins (55) Interactants (95) Wiki
XB-GENEPAGE-976484
???displayGene.symbol???:
 itch

???displayGene.name???: 
itchy E3 ubiquitin protein ligase

???displayGene.synonyms???
itchy , LOC108701064 , LOC108702762 ( Nomenclature history )

???displayGene.geneFunction???
ubiquitin-protein ligase

AI Protein Function :
The gene itch encodes an e3 ubiquitin protein ligase involved in targeting proteins for proteasomal degradation via polyubiquitination. It functions in cell adhesion signaling pathways during early dev...[+]


InterPro :
E3 ub ligase SMURF1, HECT dom, Hect E3 ubiquitin ligase, WW dom, [+]

???displayGene.geneInteractants???
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Diseases: 


MIM:
AUTOIMMUNE DISEASE, MULTISYSTEM, WITH FACIAL DYSMORPHISM; ADMFD

External Links:
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???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


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