The gene wfdc1 encodes a protein with WAP four-disulfide core domain-containing protein 1, which may function in immune response and epithelial defense mechanisms. In xenopus laevis and xenopus tropica...[+]

The gene wfdc1 encodes a protein with WAP four-disulfide core domain-containing protein 1, which may function in immune response and epithelial defense mechanisms. In xenopus laevis and xenopus tropicalis, the wfdc1 protein is expressed in epithelial tissues and may play roles in innate immunity and mucosal defense. The protein is secreted and may have antimicrobial properties. Expression is observed in skin and mucosal surfaces, indicating a role in barrier function. The protein may also be involved in developmental processes. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD