The slc11a1 gene encodes a membrane-bound divalent metal ion transporter protein localized to the membrane of late endosomes and lysosomes. This protein functions in iron homeostasis and in macrophage ...[+]

The slc11a1 gene encodes a membrane-bound divalent metal ion transporter protein localized to the membrane of late endosomes and lysosomes. This protein functions in iron homeostasis and in macrophage host defense against intracellular pathogens by regulating phagosomal pH and mediating antimicrobial activity. Expression is detected in macrophages, liver, intestine, kidney, and spleen. [-]

          BURULI ULCER, SUSCEPTIBILITY TO

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD