The gene macc1 encodes a transcription factor of the bHLH type and is involved in regulating neural crest cell migration. Its expression patterns are observed in the cranial neural crest during develop...[+]

The gene macc1 encodes a transcription factor of the bHLH type and is involved in regulating neural crest cell migration. Its expression patterns are observed in the cranial neural crest during development. The protein localizes to the nucleus where it functions by binding DNA at e-box motifs to regulate downstream target genes, influencing the epithelial-to-mesenchymal transition process. [-]

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