The gfra3 gene encodes a gdnf family receptor alpha-3 protein, which is a gpi-anchored cell surface coreceptor. This coreceptor partners with the ret receptor tyrosine kinase to form a ligand-specific ...[+]

The gfra3 gene encodes a gdnf family receptor alpha-3 protein, which is a gpi-anchored cell surface coreceptor. This coreceptor partners with the ret receptor tyrosine kinase to form a ligand-specific complex for the neurotrophic factor artemin. Its expression is detected in the developing pronephros, mesonephric kidney, branchial arches, and neural crest-derived enteric neurons. The protein functions in neuronal development and kidney morphogenesis by mediating artemin signaling. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD