The anapc11 gene encodes a core subunit of the ana phase-promoting complex/cyclosome (APC/C), which is an E3 ubiquitin ligase. This protein localizes to the nucleus and cytoplasm and functions in targe...[+]

The anapc11 gene encodes a core subunit of the ana phase-promoting complex/cyclosome (APC/C), which is an E3 ubiquitin ligase. This protein localizes to the nucleus and cytoplasm and functions in targeting specific proteins, such as cyclins and securin, for proteasomal degradation to regulate mitotic exit, control the timing of cell cycle progression, and ensure proper chromosome segregation. It operates during both mitosis and meiosis, with expression observed throughout early embryonic development, including in oocytes and various stages of embryogenesis. Its activity is necessary for establishing the dorsal-ventral axis and for regulating spindle assembly checkpoints to maintain genomic stability. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD