The reck gene encodes a gpi-anchored membrane-bound protein functioning as an inhibitor of adam family metalloproteinases, regulating extracellular matrix composition. in situ hybridization shows expre...[+]

The reck gene encodes a gpi-anchored membrane-bound protein functioning as an inhibitor of adam family metalloproteinases, regulating extracellular matrix composition. in situ hybridization shows expression localized to the developing nervous system, including the spinal cord, notochord, and cranial ganglia during embryogenesis. it is also expressed in the fin and plays a role in fin regeneration by modulating wnt signaling pathways and cell proliferation. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD