Bcl3 is a transcriptional co-regulator interacting with nf-kb p50 and p52 homodimers to activate or repress gene expression during development. It functions in the development of the neural crest, bran...[+]

Bcl3 is a transcriptional co-regulator interacting with nf-kb p50 and p52 homodimers to activate or repress gene expression during development. It functions in the development of the neural crest, branchial arches, pharyngeal pouches, and cranial cartilage. The protein localizes to the nucleus where it modulates transcription by binding dna through its interaction with nf-kb subunits. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD