The cdk2 gene encodes a cyclin-dependent kinase protein. The cdk2 protein is a serine/threonine kinase whose activity is regulated by binding to cyclins and phosphorylation; it forms a complex with cyc...[+]

The cdk2 gene encodes a cyclin-dependent kinase protein. The cdk2 protein is a serine/threonine kinase whose activity is regulated by binding to cyclins and phosphorylation; it forms a complex with cyclin e. This kinase functions in the control of the cell cycle, promoting the g1/s phase transition through phosphorylation of target substrates like the retinoblastoma protein. It is involved in dna replication during early embryonic cell cycles. Expression is detected in oocytes, eggs, and various embryonic tissues including the developing eye, brain, branchial arches, somites, notochord, and epidermis. The protein localizes to the nucleus. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD