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Summary Expression Expr. PhenotypesPheno. Gene Literature (797)Lit. (797) GO Terms (124)GO (124) Nucleotides (388)Nucl. (388) Proteins (46)Prot. (46) Interactants (1778)Interact. (1778) Wiki
XB-GENEPAGE- 479466

Show:     All X. laevis X. tropicalis

Protein sequences for mapk1 - All


Models (29)

Source Version Model Species
NCBI 10.1 XBmRNA9833 X. laevis.S
NCBI 10.1 XBmRNA4775 X. laevis.L
NCBI 10.0 mRNA045233 X. tropicalis
ENSEMBL 10.0 ENSXETP00000079571 X. tropicalis
Xenbase 9.2 rna27615 X. laevis.L
Xenbase 9.2 rna25024 X. laevis.S
JGI 9.1 Xelaev18010534m X. laevis.S
ENSEMBL 9.1 ENSXETP00000079571 X. tropicalis
ENSEMBL 9.1 ENSXETP00000040234 X. tropicalis
ENSEMBL 9.1 ENSXETP00000063518 X. tropicalis
ENSEMBL 9.1 ENSXETP00000077904 X. tropicalis
JGI 9.1 Xelaev18007690m X. laevis.L
Xenbase 9.1 rna40927 X. tropicalis
JGI 7.2 Xelaev16080283m X. laevis.S
JGI 7.1 Xetro.A00811.1 X. tropicalis
JGI 6.0 XeXenL6RMv10041064m X. laevis.S
JGI 6.0 XeXenL6RMv10047906m X. laevis.L
JGI 4.1 gw1.12.221.1 X. tropicalis
JGI 4.1 e_gw1.12.222.1 X. tropicalis
JGI 4.1 e_gw1.12.223.1 X. tropicalis
ENSEMBL 4.1 ENSXETP00000040234 X. tropicalis
JGI 4.1 fgenesh1_kg.C_scaffold_12000020 X. tropicalis
JGI 4.1 fgenesh1_pg.C_scaffold_12000079 X. tropicalis
JGI 4.1 fgenesh1_pg.C_scaffold_12000080 X. tropicalis
JGI 4.1 fgenesh1_pm.C_scaffold_12000024 X. tropicalis
JGI 4.1 fgenesh1_Sanger_cdna.C_scaffold_12000013 X. tropicalis
JGI 4.1 e_gw1.12.221.1 X. tropicalis
JGI 4.1 gw1.12.222.1 X. tropicalis
JGI 4.1 gw1.12.223.1 X. tropicalis

UniProtKB Protein Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the MAPK/ERK cascade. Depending on the cellular context, this cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Many of the substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. Phosphorylates microtubule-associated protein 2 (MAP2), myelin basic protein (MBP) and Elk-1. Phosphorylates dual specificity protein phosphatase 1 (DUSP1) during meiosis, increasing its stability. Activated by M phase promoting factor (MPF). Plays a role in the spindle assembly checkpoint.

AI Protein Function : mapk1 encodes a serine/threonine protein kinase that functions as a signaling molecule in the MAPK/ERK pathway, transducing signals that drive cell proliferation, cell cycle progression, and differentiation during embryogenesis; it is required for FGF‑induced mesoderm formation, neural induction, brain and eye development, somite segmentation, heart morphogenesis, pronephric tubule formation, notochord maintenance, and tailbud elongation; the protein is localized to the cytoplasm and translocates to the nucleus upon activation.

NCBI Proteins (17)

Accession Species Source
CAJ81851 X. tropicalis NCBI Protein
KAE8634726 X. tropicalis RefSeq
KAE8634727 X. tropicalis RefSeq
KAE8634728 X. tropicalis RefSeq
NP_001017127 X. tropicalis RefSeq
AAH60748 X. laevis.S NCBI Protein
CAA42482 X. laevis.S NCBI Protein
NP_001083548 X. laevis.S RefSeq
OCT98303 X. laevis.S NCBI Protein
AAA50002 X. laevis.L NCBI Protein
AAH76730 X. laevis.L NCBI Protein
NP_001081344 X. laevis.L RefSeq
OCU01911 X. laevis.L NCBI Protein
XP_041423626 X. laevis.L RefSeq

UniProt Proteins (3)

Accession Species Source
Q28H11 (InterPro) X. tropicalis TrEMBL
A0A974DUP6 (InterPro) X. laevis.S TrEMBL
Q6DFK6 (InterPro) X. laevis.L TrEMBL