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XB-ART-21058
Biochim Biophys Acta 1994 Jul 06;12002:224-6.
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Lipase inhibitors abolish contractions and cause depolarization in frog skeletal muscle fibres.

Bruton JD, Westerblad H, Lännergren J.


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Single, intact frog muscle fibers were exposed to bromophenylacylbromide (BPB) or nordihydroguairetic acid (NDGA). Fibres first became unable to respond to electrical stimulation and then depolarized; this process was accelerated by repeated activation. In addition BPB, but not NDGA, eventually induced a contracture in the fibre. The contractile response to direct Ca-release from the sarcoplasmic reticulum by caffeine was unaffected by the drugs.

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