Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Physiol
2005 Jun 01;565Pt 2:381-90. doi: 10.1113/jphysiol.2004.079582.
Show Gene links
Show Anatomy links
Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3.
Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll RA, McCormick JA, Wang J, Pearce D, Lang F.
???displayArticle.abstract???
Phosphatidylinositol 3 kinase (PI3-kinase) is activated during and is required for hippocampal glutamate receptor-dependent long-term potentiation. It mediates the delivery of AMPA receptors to the neuronal surface. Among the downstream targets of PI3-kinase are three members of the serum- and glucocorticoid-inducible kinase family, SGK1, SGK2 and SGK3. In Xenopus oocytes expressing the AMPA subunit GluR1, we show that SGK3, and to a lesser extent SGK2, but not SGK1, increase glutamate-induced currents by increasing the abundance of GluR1 protein in the cell membrane. We further show Sgk3 mRNA expression in the hippocampus by RT-PCR and in situ hybridization. According to Western blotting, the hippocampal abundance of GluR1 is significantly lower in gene-targeted mice lacking SGK3 (Sgk3-/-) than in their wild-type littermates (Sgk3+/+). The present observations disclose a novel mechanism in the regulation of GluR1.
Ahmadian,
Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD.
2004, Pubmed
Ahmadian,
Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD.
2004,
Pubmed Cullen,
Integration of calcium and Ras signalling.
2002,
Pubmed Debonneville,
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.
2001,
Pubmed
,
Xenbase Esteban,
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity.
2003,
Pubmed Gamaro,
Reduction of hippocampal Na+, K+-ATPase activity in rats subjected to an experimental model of depression.
2003,
Pubmed Gamper,
IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1.
2002,
Pubmed Gamper,
K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.
2002,
Pubmed
,
Xenbase Henke,
Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms.
2002,
Pubmed
,
Xenbase Hollmann,
Cloned glutamate receptors.
1994,
Pubmed Kobayashi,
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.
1999,
Pubmed Kourrich,
Kaliotoxin, a Kv1.1 and Kv1.3 channel blocker, improves associative learning in rats.
2001,
Pubmed Lang,
Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms.
2001,
Pubmed Lang,
Regulation of channels by the serum and glucocorticoid-inducible kinase - implications for transport, excitability and cell proliferation.
2003,
Pubmed Lee,
Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory.
2003,
Pubmed Li,
Lithium prevents ouabain-induced behavioral changes. Toward an animal model for manic depression.
1997,
Pubmed Lin,
A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala.
2001,
Pubmed Mack,
Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice.
2001,
Pubmed Maljevic,
C-terminal interaction of KCNQ2 and KCNQ3 K+ channels.
2003,
Pubmed
,
Xenbase Man,
Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons.
2003,
Pubmed McCormick,
Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development.
2004,
Pubmed Meador-Woodruff,
Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder.
2001,
Pubmed Park,
Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.
1999,
Pubmed Passafaro,
Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons.
2001,
Pubmed Pearce,
SGK1 regulation of epithelial sodium transport.
2003,
Pubmed Reisel,
Spatial memory dissociations in mice lacking GluR1.
2002,
Pubmed Sanna,
Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region.
2002,
Pubmed Seebohm,
Molecular determinants of KCNQ1 channel block by a benzodiazepine.
2003,
Pubmed
,
Xenbase Sheng,
Postsynaptic signaling and plasticity mechanisms.
2002,
Pubmed Sheng,
Neurobiology: glutamate receptors on the move.
2002,
Pubmed Soderling,
Postsynaptic protein phosphorylation and LTP.
2000,
Pubmed Stern-Bach,
A point mutation in the glutamate binding site blocks desensitization of AMPA receptors.
1998,
Pubmed Strutz,
Kainate-binding proteins are rendered functional ion channels upon transplantation of two short pore-flanking domains from a kainate receptor.
2002,
Pubmed
,
Xenbase Strutz-Seebohm,
Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression.
2005,
Pubmed
,
Xenbase Verrey,
SGK1: aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cells.
2003,
Pubmed
,
Xenbase Waldegger,
Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.
1997,
Pubmed Wenthold,
Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons.
1996,
Pubmed Yun,
Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras.
1998,
Pubmed Zamanillo,
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning.
1999,
Pubmed
