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XB-ART-22498
FEBS Lett 1993 Jun 14;3242:140-2.
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Recombinant GABAA receptor function and ethanol.

Sigel E, Baur R, Malherbe P.


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Different combinations of cloned subunits of the rat brain GABAA receptor were expressed in Xenopus oocytes. Possible effects of ethanol on the expressed GABA-induced chloride current were determined. The consequence of replacing the gamma 2S subunit by the alternatively spliced variant gamma 2L was specifically tested on the responsiveness to ethanol. A significant stimulation of the GABA response was only observed at very high concentrations (> 60 mM) of ethanol. No differential response was observed between subunit combinations containing different gamma 2 subunit splice variants.

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Species referenced: Xenopus
Genes referenced: gabarap