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XB-ART-23724
Biochem Biophys Res Commun 1992 May 15;1843:1484-9.
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Cloning and modulation by endothelin-1 of rat cardiac K channel.

Ishii K, Nunoki K, Murakoshi H, Taira N.


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We have cloned a delayed rectifier type K channel from rat heart (RH1). RH1 was identical to the rat brain K channel BK2 and differed from recently cloned rat cardiac K channel RAK by one amino acid residue. Endothelin receptors(ETRs)-mediated modulation of RH1 current (IRH1) was studied using Xenopus oocyte expression system. Activation of two different subtypes of ETRs by endothelin-1 equally suppressed the amplitude of IRH1. Stimulation of phosphatidylinositol turnover will probably be responsible for the suppression.

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Species referenced: Xenopus laevis
Genes referenced: bdkrb2 edn1 rho