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Mol Cell Biol
1992 Jan 01;121:302-8. doi: 10.1128/mcb.12.1.302-308.1992.
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Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals.
Diaz-Meco MT, Dominguez I, Sanz L, Municio MM, Berra E, Cornet ME, Garcia de Herreros A, Johansen T, Moscat J.
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Cell growth and tumor transformation can be restrained in certain cell systems by the action of transforming growth factor beta (TGF-beta). It has been established that the mechanism whereby TGF-beta 1 inhibits cell growth does not interfere with the triggering of early mitogenic signal transduction mechanisms. Phospholipase C-catalyzed hydrolysis of phosphatidylcholine (PC) is a relatively late step in the cascade activated by growth factors. Therefore, conceivably activation of phospholipase C-catalyzed hydrolysis of PC could be the target of TGF-beta 1 action. In the study reported here, we demonstrate that TGF-beta 1 inhibits the coupling of ras p21 to the activation of PC hydrolysis, which appears to be critical for the antiproliferative effects of TGF-beta 1.
Barbacid,
ras genes.
1987,
Pubmed Berridge,
Inositol trisphosphate and diacylglycerol: two interacting second messengers.
1987,
Pubmed Birchmeier,
ras proteins can induce meiosis in Xenopus oocytes.
1985,
Pubmed
,
Xenbase BLIGH,
A rapid method of total lipid extraction and purification.
1959,
Pubmed Cantley,
Oncogenes and signal transduction.
1991,
Pubmed Coffey,
Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta.
1988,
Pubmed Cross,
Growth factors in development, transformation, and tumorigenesis.
1991,
Pubmed Diaz-Meco,
Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by muscarinic agonists.
1989,
Pubmed Doolittle,
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.
1983,
Pubmed Exton,
Signaling through phosphatidylcholine breakdown.
1990,
Pubmed García de Herreros,
Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21.
1991,
Pubmed
,
Xenbase Hunter,
Cooperation between oncogenes.
1991,
Pubmed Johansen,
Cloning and sequencing of the gene encoding the phosphatidylcholine-preferring phospholipase C of Bacillus cereus.
1988,
Pubmed Korn,
Ras p21 as a potential mediator of insulin action in Xenopus oocytes.
1987,
Pubmed
,
Xenbase Laiho,
Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II.
1991,
Pubmed Laiho,
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation.
1990,
Pubmed Larrodera,
Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis.
1990,
Pubmed Like,
The antiproliferative effect of type beta transforming growth factor occurs at a level distal from receptors for growth-activating factors.
1986,
Pubmed Little,
Phospholipase C.
1989,
Pubmed Lopez-Barahona,
Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade.
1990,
Pubmed Lyons,
Transforming growth factors and the regulation of cell proliferation.
1990,
Pubmed Moscat,
The calcium signal for Balb/MK keratinocyte terminal differentiation induces sustained alterations in phosphoinositide metabolism without detectable protein kinase C activation.
1989,
Pubmed Moses,
TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights.
1990,
Pubmed Murray,
Cyclin synthesis drives the early embryonic cell cycle.
1989,
Pubmed
,
Xenbase Myrnes,
A simple purification scheme yielding crystalline phospholipase C from Bacillus cereus.
1980,
Pubmed Pietenpol,
TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.
1990,
Pubmed Price,
Stimulation of phosphatidylcholine hydrolysis, diacylglycerol release, and arachidonic acid production by oncogenic ras is a consequence of protein kinase C activation.
1989,
Pubmed Smith,
Requirement for c-ras proteins during viral oncogene transformation.
,
Pubmed Weissman,
Members of the src and ras oncogene families supplant the epidermal growth factor requirement of BALB/MK-2 keratinocytes and induce distinct alterations in their terminal differentiation program.
1985,
Pubmed
