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EMBO J
1987 Mar 01;63:767-77. doi: 10.1002/j.1460-2075.1987.tb04819.x.
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Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development.
Regulski M, McGinnis N, Chadwick R, McGinnis W.
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The characteristic morphology of many elements of the Drosophila body plan is crucially dependent upon the proper spatial expression of homeotic selector genes. The Deformed locus, which we isolated by virtue of its homology to the homeo box, is a candidate for a homeotic selector in the head region of the developing embryo. Here we show that null mutants of Deformed result in a loss of pattern elements derived from the maxillary and mandibular segments, and a duplication of a cuticular element of the larval headskeleton. Molecular analysis of the locus shows that Dfd transcripts are encoded in five exons distributed over 11 kb. The major transcript of 2.8 kb contains a 1758-bp open reading frame that would translate to yield a 63.5-kd protein containing a homeo domain and conspicuous regions of monotonic amino acid sequences. The Dfd protein exhibits extensive homology to a protein encoded by a Xenopus homeo box gene, Xhox 1A, suggesting that the Xenopus gene is the frog homologue of Dfd.
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Akam,
The location of Ultrabithorax transcripts in Drosophila tissue sections.
1983,
Pubmed Akam,
The distribution of Ultrabithorax transcripts in Drosophila embryos.
1985,
Pubmed Beachy,
Segmental distribution of bithorax complex proteins during Drosophila development.
,
Pubmed Bender,
Molecular Genetics of the Bithorax Complex in Drosophila melanogaster.
1983,
Pubmed Breathnach,
Organization and expression of eucaryotic split genes coding for proteins.
1981,
Pubmed Burke,
High-sensitivity S1 mapping with single-stranded [32P]DNA probes synthesized from bacteriophage M13mp templates.
1984,
Pubmed Garber,
Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila.
1983,
Pubmed Hafen,
Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila.
,
Pubmed Harding,
Spatially regulated expression of homeotic genes in Drosophila.
1985,
Pubmed Harvey,
Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products.
1986,
Pubmed
,
Xenbase Hazelrigg,
Revertants of Dominant Mutations Associated with the Antennapedia Gene Complex of DROSOPHILA MELANOGASTER: Cytology and Genetics.
1983,
Pubmed Horridge,
Critical point drying for scanning electron microscopic sthdy of ciliary motion.
1969,
Pubmed Hultmark,
Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22.
1986,
Pubmed Joyner,
Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene.
1985,
Pubmed Karch,
The abdominal region of the bithorax complex.
1985,
Pubmed Kaufman,
Cytogenetic Analysis of Chromosome 3 in DROSOPHILA MELANOGASTER: Isolation and Characterization of Four New Alleles of the Proboscipedia (pb) Locus.
1978,
Pubmed Kozak,
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.
1986,
Pubmed Kuroiwa,
Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts.
1985,
Pubmed Langer-Safer,
Immunological method for mapping genes on Drosophila polytene chromosomes.
1982,
Pubmed Laughon,
Common properties of proteins encoded by the Antennapedia complex genes of Drosophila melanogaster.
1985,
Pubmed Lewis,
Genetic Analysis of the Antennapedia Gene Complex (Ant-C) and Adjacent Chromosomal Regions of DROSOPHILA MELANOGASTER. II. Polytene Chromosome Segments 84A-84B1,2.
1980,
Pubmed Lewis,
A gene complex controlling segmentation in Drosophila.
1978,
Pubmed Maxam,
Sequencing end-labeled DNA with base-specific chemical cleavages.
1980,
Pubmed McGinnis,
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes.
,
Pubmed Mitchison,
Localization of antigenic determinants in whole Drosophila embryos.
1983,
Pubmed Mount,
A catalogue of splice junction sequences.
1982,
Pubmed Poole,
The engrailed locus of Drosophila: structural analysis of an embryonic transcript.
1985,
Pubmed Proudfoot,
3' non-coding region sequences in eukaryotic messenger RNA.
1976,
Pubmed Regulski,
Homeo box genes of the Antennapedia and bithorax complexes of Drosophila.
1985,
Pubmed Sánchez-Herrero,
Genetic organization of Drosophila bithorax complex.
,
Pubmed Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed Schneuwly,
Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster.
1986,
Pubmed Scott,
The molecular organization of the Antennapedia locus of Drosophila.
1983,
Pubmed Sheridan,
Amino acid composition and hydrophobicity patterns of protein domains correlate with their structures.
1985,
Pubmed Struhl,
Genes controlling segmental specification in the Drosophila thorax.
1982,
Pubmed Struhl,
Role of the esc+ gene product in ensuring the selective expression of segment-specific homeotic genes in Drosophila.
1983,
Pubmed Turner,
Scanning electron microscopy of Drosophila melanogaster embryogenesis. III. Formation of the head and caudal segments.
1979,
Pubmed Wakimoto,
Defects in embryogenesis in mutants associated with the antennapedia gene complex of Drosophila melanogaster.
1984,
Pubmed Wharton,
opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster.
1985,
Pubmed White,
Distribution of Ultrabithorax proteins in Drosophila.
1985,
Pubmed
