Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
S1 mapping of Xenopus laevis ribosomal RNA transcripts, both in oocyte microinjection experiments and in vivo, shows that all but 212 bp of the so-called "non-transcribed" spacer (NTS) of the ribosomal DNA repeat is transcribed as part of the primary ribosomal transcript. The 40S pre-ribosomal RNA (pre-rRNA) is therefore a processing intermediate. The primary ribosomal transcript co-terminates with the previously described spacer transcripts [Moss], at a site 213 bp upstream of the 40S pre-rRNA initiation site. This mode of transcription suggests a simple mechanism for the recently proposed phenomenon of "readthrough-enhancement", [Moss et al, Moss], where readthrough transcription from an upstream gene may enhance transcription of a gene immediately downstream in the tandem ribosomal repeat.
Bakken,
Mapping of transcription initiation and termination signals on Xenopus laevis ribosomal DNA.
1982, Pubmed,
Xenbase
Bakken,
Mapping of transcription initiation and termination signals on Xenopus laevis ribosomal DNA.
1982,
Pubmed
,
Xenbase Birnstiel,
The ribosomal RNA cistrons.
1971,
Pubmed Grummt,
Spacer sequences downstream of the 28S RNA coding region are part of the mouse rDNA transcription unit.
1985,
Pubmed Grummt,
Transcription of mouse rDNA terminates downstream of the 3' end of 28S RNA and involves interaction of factors with repeated sequences in the 3' spacer.
1985,
Pubmed Labhart,
Xenopus ribosomal gene enhancers function when inserted inside the gene they enhance.
1985,
Pubmed
,
Xenbase Labhart,
Characterization of three sites of RNA 3' end formation in the Xenopus ribosomal gene spacer.
1986,
Pubmed
,
Xenbase Miller,
Morphological studies of transcription.
1972,
Pubmed Miller,
Extrachromosomal nucleolar genes in amphibian oocytes.
1969,
Pubmed Moss,
The promotion of ribosomal transcription in eukaryotes.
1985,
Pubmed Moss,
Transcription of cloned Xenopus laevis ribosomal DNA microinjected into Xenopus oocytes, and the identification of an RNA polymerase I promoter.
1982,
Pubmed
,
Xenbase Perry,
The nucleolus and the synthesis of ribosomes.
1967,
Pubmed Reeder,
Sites of transcription initiation in vivo on Xenopus laevis ribosomal DNA.
1977,
Pubmed
,
Xenbase Sollner-Webb,
The nucleotide sequence of the initiation and termination sites for ribosomal RNA transcription in X. laevis.
1979,
Pubmed
,
Xenbase Tautz,
Transcription of the tandem array of ribosomal DNA in Drosophila melanogaster does not terminate at any fixed point.
1986,
Pubmed Trendelenburg,
Chromatin structure of Xenopus rDNA transcription termination sites. Evidence for a two-step process of transcription termination.
1982,
Pubmed
,
Xenbase Trendelenburg,
Transcription of cloned Xenopus ribosomal genes visualised after injection into oocyte nuclei.
1978,
Pubmed
,
Xenbase
