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XB-ART-38920
Methods Mol Biol 2008 Jan 01;468:145-56. doi: 10.1007/978-1-59745-249-6_11.
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Image analysis of calcium release dynamics.

Freisinger CM, Houston DW, Slusarski DC.


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Many aspects of animal development are dependent on the dynamic release of calcium (Ca2+) ions. Although Ca2+ release within a cell is tightly controlled, how the release dynamics result in a specific biological output in embryonic development is less clear. The integration of pharmacological and molecular-genetic studies with in vivo imaging in zebrafish and Xenopus has linked endogenous Ca2+ release to the Wnt signaling network. Our data suggests that distinct Ca2+ release dynamics lead to antagonism of the developmentally important Wnt/beta-catenin pathway while sustained Ca2+ release modulates polarized cell movements.

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