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Nkx5 family members are homeobox transcription factors important for sensory organ development. Several members of the Nkx5 family are expressed in the eye, brain, developing ear, and lateral line. Members of this family have been previously identified in medaka, chick, and mouse. Here, we characterize two members of the Nkx5 family, Nkx5.3 and SOHo, in Xenopus laevis. We verify the identity of X. laevis Nkx5.3 and SOHo by phylogenetic comparison to chicken, medaka, and zebrafish orthologs. Both Nkx5.3 and SOHo are expressed in the developing eye, ear, lateral line system, and cranial neurons as determined by in situ hybridization.
Adamska,
Five Nkx5 genes show differential expression patterns in anlagen of sensory organs in medaka: insight into the evolution of the gene family.
2001, Pubmed
Adamska,
Five Nkx5 genes show differential expression patterns in anlagen of sensory organs in medaka: insight into the evolution of the gene family.
2001,
Pubmed Deitcher,
Asymmetric expression of a novel homeobox gene in vertebrate sensory organs.
1994,
Pubmed Mitton,
The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation.
2000,
Pubmed Perron,
The genetic sequence of retinal development in the ciliary margin of the Xenopus eye.
1998,
Pubmed
,
Xenbase Saha,
A Xenopus homebox gene defines dorsal-ventral domains in the developing brain.
1993,
Pubmed
,
Xenbase Schlosser,
Early embryonic specification of vertebrate cranial placodes.
2014,
Pubmed
,
Xenbase Schorderet,
Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome.
2008,
Pubmed Stadler,
Characterization of the homeobox-containing gene GH6 identifies novel regions of homeobox gene expression in the developing chick embryo.
1994,
Pubmed Viczian,
XOtx5b and XOtx2 regulate photoreceptor and bipolar fates in the Xenopus retina.
2003,
Pubmed
,
Xenbase Wang,
Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila.
2000,
Pubmed Whitaker,
Conserved transcriptional activators of the Xenopus rhodopsin gene.
2004,
Pubmed
,
Xenbase
