Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Adv Neurobiol
2022 Jan 01;28:87-107. doi: 10.1007/978-3-031-07167-6_4.
Show Gene links
Show Anatomy links
Homeostatic Regulation of Motoneuron Properties in Development.
Wenner PA, Pekala D.
???displayArticle.abstract???
Homeostatic plasticity represents a set of compensatory mechanisms that are engaged following a perturbation to some feature of neuronal or network function. Homeostatic mechanisms are most robustly expressed during development, a period that is replete with various perturbations such as increased cell size and the addition/removal of synaptic connections. In this review we look at numerous studies that have advanced our understanding of homeostatic plasticity by taking advantage of the accessibility of developing motoneurons. We discuss the homeostatic regulation of embryonic movements in the living chick embryo and describe the spinal compensatory mechanisms that act to recover these movements (homeostatic intrinsic plasticity) or stabilize synaptic strength (synaptic scaling). We describe the expression and triggering mechanisms of these forms of homeostatic plasticity and thereby gain an understanding of their roles in the motor system. We then illustrate how these findings can be extended to studies of developing motoneurons in other systems including the rodents, zebrafish, and fly. Furthermore, studies in developing drosophila have been critical in identifying some of the molecular signaling cascades and expression mechanisms that underlie homeostatic intrinsic membrane excitability. This powerful model organism has also been used to study a presynaptic form of homeostatic plasticity where increases or decreases in synaptic transmission are associated with compensatory changes in probability of release at the neuromuscular junction. Further, we describe studies that demonstrate homeostatic adjustments of ion channel expression following perturbations to other kinds of ion channels. Finally, we discuss work in xenopus that shows a homeostatic regulation of neurotransmitter phenotype in developing motoneurons following activity perturbations. Together, this work illustrates the importance of developing motoneurons in elucidating the mechanisms and roles of homeostatic plasticity.
Aoto,
Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity.
2008, Pubmed
Aoto,
Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity.
2008,
Pubmed Baines,
Postsynaptic protein kinase A reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS.
2003,
Pubmed Baines,
Altered electrical properties in Drosophila neurons developing without synaptic transmission.
2001,
Pubmed Belgacem,
Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord.
2011,
Pubmed
,
Xenbase Ben-Ari,
Developing networks play a similar melody.
2001,
Pubmed Ben-Ari,
Giant synaptic potentials in immature rat CA3 hippocampal neurones.
1989,
Pubmed Bergquist,
A hierarchy of cell intrinsic and target-derived homeostatic signaling.
2010,
Pubmed Borodinsky,
Crosstalk among electrical activity, trophic factors and morphogenetic proteins in the regulation of neurotransmitter phenotype specification.
2016,
Pubmed Borodinsky,
Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction.
2007,
Pubmed
,
Xenbase Borodinsky,
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons.
2004,
Pubmed
,
Xenbase Cholanian,
Influence of developmental nicotine exposure on glutamatergic neurotransmission in rhythmically active hypoglossal motoneurons.
2017,
Pubmed Chub,
Blockade and recovery of spontaneous rhythmic activity after application of neurotransmitter antagonists to spinal networks of the chick embryo.
1998,
Pubmed Daniels,
Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content.
2004,
Pubmed Davis,
Homeostatic control of neural activity: from phenomenology to molecular design.
2006,
Pubmed Davis,
Genetic analysis of synaptic development and plasticity: homeostatic regulation of synaptic efficacy.
1998,
Pubmed Davis,
Synapse-specific control of synaptic efficacy at the terminals of a single neuron.
1998,
Pubmed Desai,
Plasticity in the intrinsic excitability of cortical pyramidal neurons.
1999,
Pubmed DiAntonio,
Glutamate receptor expression regulates quantal size and quantal content at the Drosophila neuromuscular junction.
1999,
Pubmed Farrant,
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
2007,
Pubmed Fedirchuk,
Spontaneous network activity transiently depresses synaptic transmission in the embryonic chick spinal cord.
1999,
Pubmed Feller,
Spontaneous correlated activity in developing neural circuits.
1999,
Pubmed Fong,
Upward synaptic scaling is dependent on neurotransmission rather than spiking.
2015,
Pubmed Fortin,
Rhythm generation in the segmented hindbrain of chick embryos.
1995,
Pubmed Frank,
Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis.
2006,
Pubmed Frank,
A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels.
2009,
Pubmed Frank,
Homeostatic control of Drosophila neuromuscular junction function.
2020,
Pubmed Garcia-Bereguiain,
In vivo synaptic scaling is mediated by GluA2-lacking AMPA receptors in the embryonic spinal cord.
2013,
Pubmed Garcia-Bereguiain,
Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo.
2016,
Pubmed Genç,
Target-wide Induction and Synapse Type-Specific Robustness of Presynaptic Homeostasis.
2019,
Pubmed Giachello,
Inappropriate Neural Activity during a Sensitive Period in Embryogenesis Results in Persistent Seizure-like Behavior.
2015,
Pubmed Giachello,
Regulation of motoneuron excitability and the setting of homeostatic limits.
2017,
Pubmed Goel,
Disparate Postsynaptic Induction Mechanisms Ultimately Converge to Drive the Retrograde Enhancement of Presynaptic Efficacy.
2017,
Pubmed Goel,
Homeostatic scaling of active zone scaffolds maintains global synaptic strength.
2019,
Pubmed Gonzalez-Islas,
Spontaneous network activity in the embryonic spinal cord regulates AMPAergic and GABAergic synaptic strength.
2006,
Pubmed Gonzalez-Islas,
NKCC1 and AE3 appear to accumulate chloride in embryonic motoneurons.
2009,
Pubmed Gonzalez-Islas,
GABAergic synaptic scaling in embryonic motoneurons is mediated by a shift in the chloride reversal potential.
2010,
Pubmed Gonzalez-Islas,
Tonic nicotinic transmission enhances spinal GABAergic presynaptic release and the frequency of spontaneous network activity.
2016,
Pubmed Gratz,
Endogenous Tagging Reveals Differential Regulation of Ca2+ Channels at Single Active Zones during Presynaptic Homeostatic Potentiation and Depression.
2019,
Pubmed Gummer,
Patterned neural activity in brain stem auditory areas of a prehearing mammal, the tammar wallaby (Macropus eugenii).
1994,
Pubmed Haghighi,
Retrograde control of synaptic transmission by postsynaptic CaMKII at the Drosophila neuromuscular junction.
2003,
Pubmed Hall,
Paralysis and growth of the musculoskeletal system in the embryonic chick.
1990,
Pubmed Hanson,
Normal patterns of spontaneous activity are required for correct motor axon guidance and the expression of specific guidance molecules.
2004,
Pubmed Ho,
Spontaneous activity in the perinatal trigeminal nucleus of the rat.
1999,
Pubmed Hou,
Homeostatic regulation of AMPA receptor expression at single hippocampal synapses.
2008,
Pubmed Itaya,
Evolution of spontaneous activity in the developing rat superior colliculus.
1995,
Pubmed Kikuma,
Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling.
2019,
Pubmed Kilman,
Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses.
2002,
Pubmed Kim,
Nonreciprocal homeostatic compensation in Drosophila potassium channel mutants.
2017,
Pubmed Kiragasi,
A Presynaptic Glutamate Receptor Subunit Confers Robustness to Neurotransmission and Homeostatic Potentiation.
2017,
Pubmed Kiragasi,
The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation.
2020,
Pubmed Knogler,
Synaptic scaling and the development of a motor network.
2010,
Pubmed Kuner,
A genetically encoded ratiometric indicator for chloride: capturing chloride transients in cultured hippocampal neurons.
2000,
Pubmed Lee,
N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
2015,
Pubmed Li,
A Glutamate Homeostat Controls the Presynaptic Inhibition of Neurotransmitter Release.
2018,
Pubmed Lin,
Activity-dependent alternative splicing increases persistent sodium current and promotes seizure.
2012,
Pubmed Lindsly,
Activity blockade and GABAA receptor blockade produce synaptic scaling through chloride accumulation in embryonic spinal motoneurons and interneurons.
2014,
Pubmed Lindsly,
Elevated intracellular Na+ concentrations in developing spinal neurons.
2017,
Pubmed Lippe,
Relationship between frequency of spontaneous bursting and tonotopic position in the developing avian auditory system.
1995,
Pubmed Lissin,
Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors.
1998,
Pubmed MacLean,
Activity-independent homeostasis in rhythmically active neurons.
2003,
Pubmed
,
Xenbase Maghsoodi,
Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity.
2008,
Pubmed Marley,
Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant.
2011,
Pubmed Mee,
Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene.
2004,
Pubmed Müller,
Transsynaptic control of presynaptic Ca²⁺ influx achieves homeostatic potentiation of neurotransmitter release.
2012,
Pubmed Müller,
RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool.
2012,
Pubmed Muraro,
Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneurons.
2008,
Pubmed Newman,
Input-Specific Plasticity and Homeostasis at the Drosophila Larval Neuromuscular Junction.
2017,
Pubmed O'Brien,
Activity-dependent modulation of synaptic AMPA receptor accumulation.
1998,
Pubmed O'Donovan,
Mechanisms of spontaneous activity in developing spinal networks.
1998,
Pubmed Paradis,
Homeostatic control of presynaptic release is triggered by postsynaptic membrane depolarization.
2001,
Pubmed Petersen,
Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release.
1997,
Pubmed Picton,
Sodium Pumps Mediate Activity-Dependent Changes in Mammalian Motor Networks.
2017,
Pubmed Picton,
Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons.
2018,
Pubmed
,
Xenbase Pilarski,
Developmental nicotine exposure alters neurotransmission and excitability in hypoglossal motoneurons.
2011,
Pubmed Plomp,
Adaptation of quantal content to decreased postsynaptic sensitivity at single endplates in alpha-bungarotoxin-treated rats.
1992,
Pubmed Rich,
Sensing and expressing homeostatic synaptic plasticity.
2007,
Pubmed Rivera,
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.
1999,
Pubmed Rosenberg,
Calcium signaling in neuronal development.
2011,
Pubmed Sutton,
Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis.
2006,
Pubmed Swapna,
Interplay between electrical activity and bone morphogenetic protein signaling regulates spinal neuron differentiation.
2012,
Pubmed
,
Xenbase Thiagarajan,
Adaptation to synaptic inactivity in hippocampal neurons.
2005,
Pubmed Turrigiano,
The self-tuning neuron: synaptic scaling of excitatory synapses.
2008,
Pubmed Turrigiano,
Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function.
2012,
Pubmed Turrigiano,
Activity-dependent changes in the intrinsic properties of cultured neurons.
1994,
Pubmed Turrigiano,
Activity-dependent scaling of quantal amplitude in neocortical neurons.
1998,
Pubmed Wang,
Homeostatic synaptic plasticity at the neuromuscular junction in myasthenia gravis.
2018,
Pubmed Wenner,
Identification of an interneuronal population that mediates recurrent inhibition of motoneurons in the developing chick spinal cord.
1999,
Pubmed Weyhersmüller,
Rapid active zone remodeling during synaptic plasticity.
2011,
Pubmed Wilhelm,
GABAA transmission is a critical step in the process of triggering homeostatic increases in quantal amplitude.
2008,
Pubmed Wilhelm,
Compensatory changes in cellular excitability, not synaptic scaling, contribute to homeostatic recovery of embryonic network activity.
2009,
Pubmed Wollman,
Developmental nicotine exposure alters glycinergic neurotransmission to hypoglossal motoneurons in neonatal rats.
2018,
Pubmed Wollman,
Developmental plasticity of GABAergic neurotransmission to brainstem motoneurons.
2018,
Pubmed Wong,
Retinal waves and visual system development.
1999,
Pubmed Younger,
A presynaptic ENaC channel drives homeostatic plasticity.
2013,
Pubmed Zhang,
Short-term memory of motor network performance via activity-dependent potentiation of Na+/K+ pump function.
2012,
Pubmed
,
Xenbase
