Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-60784
Sci Adv 2023 Aug 02;931:eadi0482. doi: 10.1126/sciadv.adi0482.
Show Gene links Show Anatomy links

Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development.

Gonzalez Lopez M , Huteckova B , Lavicky J , Zezula N , Rakultsev V , Fridrichova V , Tuaima H , Nottmeier C , Petersen J , Kavkova M , Zikmund T , Kaiser J , Lav R , Star H , Bryja V , Henyš P , Vořechovský M , Tucker AS , Harnos J , Buchtova M , Krivanek J .


???displayArticle.abstract???
Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been intensely studied, there is currently no tool to accurately follow the dynamics of growth and healing of these vital tissues in space and time. Here, we present the BEE-ST (Bones and tEEth Spatio-Temporal growth monitoring) approach, which allows precise quantification of development, regeneration, remodeling, and healing in any type of calcified tissue across different species. Using mouse teeth as model the turnover rate of continuously growing incisors was quantified, and role of hard/soft diet on molar root growth was shown. Furthermore, the dynamics of bones and teeth growth in lizards, frogs, birds, and zebrafish was uncovered. This approach represents an effective, highly reproducible, and versatile tool that opens up diverse possibilities in developmental biology, bone and tooth healing, tissue engineering, and disease modeling.

???displayArticle.pubmedLink??? 37531427
???displayArticle.pmcLink??? PMC10396306
???displayArticle.link??? Sci Adv



References [+] :
Acar, Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. 2015, Pubmed