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XB-GRNA-29231171
gRNA Name:
neurod2 gRNA3
Synonyms: Rnk5
Genomic Target: neurod2
PAM Sequence: TGG
Sequence: 5' GGCGAGAGGCCCAAAAAACG 3'
Synonyms: Rnk5
Genomic Target: neurod2
PAM Sequence: TGG
Sequence: 5' GGCGAGAGGCCCAAAAAACG 3'
| Genomic Target | tropicalis | laevis.L | laevis.S | ||||
| Identities | 19/20 | 20/20 | 20/20 | ||||
genome
gRNA
|
5' CGTTTTTTGGGCCTCTCACC 3'
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3' GCAAAAAACCCGGAGAGCGG 5' |
5' CGTTTTTTGGGCCTCTCGCC 3' |||||||||||||||||||| 3' GCAAAAAACCCGGAGAGCGG 5' |
5' CGTTTTTTGGGCCTCTCGCC 3' |||||||||||||||||||| 3' GCAAAAAACCCGGAGAGCGG 5' |
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Genomic Alignments  |
Position | Identity | Strand | Target | Genomic Target | ||
| laevis 10.1 | Chr9_10S:2071341..2071360 | 20/20 | Sense | target | neurod2.S | ||
| Chr9_10L:2323346..2323365 | 20/20 | Sense | target | neurod2.L | |||
| Chr1S:121382942..121382961 | 17/20 | Sense | off-target | rorb.S | |||
| Chr6L:6658779..6658798 | 16/20 | Sense | off-target | LOC121394782 | |||
| Chr7S:77388958..77388977 | 18/20 | unknown | tropicalis 10.0 | Chr10:10065176..10065195 | 19/20 | Sense | target | neurod2 |
| Chr3:26468471..26468490 | 18/20 | Antisense | off-target | sting1 | |||
| Chr6:34726219..34726238 | 16/20 | Sense | off-target | nxph1 | |||
| Chr3:119115534..119115553 | 16/20 | unknown | |||||
| Publications | |||||||
| ???morpholino.displaySummary.papersFirst??? |
Knockdown of NeuroD2 leads to seizure-like behaviour, brain neuronal hyperactivity and a leaky blood-brain barrier in a Xenopus laevis tadpole model of DEE75., Genetics 2024  |
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| ???morpholino.displaySummary.papersRecent??? | |||||||
| ???morpholino.displaySummary.papersAll??? | |||||||
