The arrb2 protein functions as a G-protein-coupled receptor kinase adaptor and scaffold protein, involved in desensitization and internalization of activated G-protein-coupled receptors like the Frizzl...[+]

The arrb2 protein functions as a G-protein-coupled receptor kinase adaptor and scaffold protein, involved in desensitization and internalization of activated G-protein-coupled receptors like the Frizzled receptors for Wnt signaling. It facilitates the internalization of Frizzled-4 and regulates the non-canonical Wnt/planar cell polarity pathway by interacting with dishevelled proteins. The protein is cytoplasmic and membrane-associated, translocating to the nucleus upon receptor activation where it can act as a co-transcriptional regulator. Expression is detected in the neural crest, cranial ganglia, eye, and brain during development. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD