Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator tha...[+]

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. [-]

             breast cancer
             choroid plexus papilloma
             Li-Fraumeni syndrome
             high grade glioma
             osteosarcoma
             bone osteosarcoma
             adrenocortical carcinoma
             pancreatic carcinoma
             lung small cell carcinoma
             choroid plexus carcinoma
             hepatocellular carcinoma
             colorectal cancer
             nasopharynx carcinoma
             Li-Fraumeni syndrome 1

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD