The ccnb1 gene encodes cyclin b1, a regulatory protein that binds and activates the kinase cdk1 to form maturation-promoting factor, which controls the g2/m transition of the cell cycle. The protein lo...[+]

The ccnb1 gene encodes cyclin b1, a regulatory protein that binds and activates the kinase cdk1 to form maturation-promoting factor, which controls the g2/m transition of the cell cycle. The protein localizes to the nucleus and cytoplasm and is required for spindle assembly and meiotic progression during oocyte maturation. Its expression and periodic degradation are necessary for proper embryonic cell divisions following fertilization. [-]

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