The gene fas encodes a death receptor that is a member of the tumor necrosis factor receptor superfamily. The fas protein functions in apoptosis signaling through the extrinsic pathway by transducing c...[+]

The gene fas encodes a death receptor that is a member of the tumor necrosis factor receptor superfamily. The fas protein functions in apoptosis signaling through the extrinsic pathway by transducing cell death signals upon ligand binding. It is a type i transmembrane protein localized to the plasma membrane. Expression is detected in the brain, spinal cord, and immune system tissues. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD