The foxe3 protein is a forkhead box transcription factor localized to the nucleus. It binds DNA through its forkhead domain to regulate gene transcription. Expression begins in the pre-lens ectoderm an...[+]

The foxe3 protein is a forkhead box transcription factor localized to the nucleus. It binds DNA through its forkhead domain to regulate gene transcription. Expression begins in the pre-lens ectoderm and later continues within the lens vesicle and differentiating lens fiber cells during eye development. Its function involves regulating the expression of genes required for lens development, including those encoding crystalline proteins. It is implicated in maintaining the proper formation and transparency of the lens and cornea. [-]

             Peters anomaly
             cataract 34 multiple types
             congenital aphakia
             anterior segment dysgenesis 2
             anterior segment dysgenesis 1

          ANTERIOR SEGMENT DYSGENESIS 2; ASGD2
          AORTIC ANEURYSM, FAMILIAL THORACIC 11, SUSCEPTIBILITY TO; AAT11
          CATARACT 34, MULTIPLE TYPES; CTRCT34

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD