The jun protein is a bZIP transcription factor. It forms heterodimers with fos family proteins to create the AP-1 transcription complex, which binds TPA-response elements to regulate gene expression in...[+]

The jun protein is a bZIP transcription factor. It forms heterodimers with fos family proteins to create the AP-1 transcription complex, which binds TPA-response elements to regulate gene expression in response to phorbol esters and other stimuli. Its subcellular localization is nuclear. Expression is detected during development in the cement gland, brain, cranial neural crest, branchial arches, notochord, somites, pronephros, and tailbud. It functions in processes including anterior-posterior patterning, somitogenesis, craniofacial development, and tissue regeneration. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD