The mapk1 gene encodes a serine/threonine kinase that functions as a mitogen-activated protein kinase. This protein is a central component of intracellular signaling cascades, including those initiated...[+]

The mapk1 gene encodes a serine/threonine kinase that functions as a mitogen-activated protein kinase. This protein is a central component of intracellular signaling cascades, including those initiated by FGF and Wnt, transducing extracellular signals to regulate cellular responses. Its phosphorylation and activation are required for processes such as mesoderm induction, neural development, and convergent extension movements during gastrulation. The activated mapk1 protein translocates from the cytoplasm to the nucleus. Expression and function are documented in the dorsal blastopore lip (the organizer), notochord, somites, and neural tissues. [-]

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