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XB-PHENO-24811

Xtr Wt + rb1 CRISPR + rbl1 CRISPR, Naert T et al. (2016)

Experiment + Assay: Xtr Wt + rb1 CRISPR + rbl1 CRISPR + tadpole (whole-mount microscopy)
Background: Xtr.inbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR rb1 gRNA2 rb1
 NF stage 2 (2-cell) blastomere
CRISPR rbl1 gRNA2 rbl1
 NF stage 2 (2-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
whole-mount microscopy NF stage 50 to NF stage 59  
Anatomical Phenotypes: abnormally localised lens, increased size of the eye, neoplastic eye
Human Disease Associations: retinoblastoma
Source: Fig.1.b
Article: XB-ART-52598, PubMed