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XB-PHENO-27382

Xla Wt + pias4 MO, Hutlet B and Schlosser G (2025)

Experiment + Assay: Xla Wt + pias4 MO + NF13-14 (in situ hybridization)
Background: Xla.outbredXen1
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection pias4 MO2 pias4 (Xla)
 NF stage 5 (16-cell) animal blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 13 to NF stage 14  
Anatomical Phenotypes: decreased size of the preplacodal ectoderm
Expression Phenotypes (11):
decreased amount eya1.L expression in cranial placode
increased amount foxd3.L expression in neuroectoderm
decreased amount foxd3.L expression in neuroectoderm
decreased amount neurod1.L expression in cranial placode
decreased amount neurod1.L expression in neuroectoderm
decreased amount neurog1.L expression in neuroectoderm
decreased amount neurog2.L expression in neuroectoderm
decreased amount six1.L expression in cranial placode
mislocalised sox3.L expression in embryo
increased amount sox3.L expression in non-neural ectoderm
decreased amount tubb2b.L expression in neuroectoderm
Source: Fig. 5, Table2
Article: XB-ART-61519, PubMed