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XB-PHENO-27383

Xla Wt + pias4, Hutlet B and Schlosser G (2025)

Experiment + Assay: Xla Wt + pias4 + NF13-14 (in situ hybridization)
Background: Xla.outbredXen1
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection pias4.L pias4.L
 NF stage 5 (16-cell)
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 13 to NF stage 14  
Anatomical Phenotypes: decreased size of the preplacodal ectoderm
Expression Phenotypes (11):
decreased amount eya1.L expression in cranial placode
decreased amount foxd3.L expression in cranial neural crest
decreased amount foxd3.L expression in neuroectoderm
decreased amount neurod1.L expression in neuroectoderm
decreased amount neurog1.L expression in neuroectoderm
decreased amount neurog2.L expression in neuroectoderm
decreased amount six1.L expression in cranial placode
mislocalised sox3.L expression in embryo
decreased amount sox3.L expression in neural plate
mislocalised sox3.L expression in non-neural ectoderm
decreased amount tubb2b.L expression in neuroectoderm
Source: Fig. 6, Table 2
Article: XB-ART-61519, PubMed