Figure 2. The relative abundance of hERG1a and hERG1b determines the ‘peak potential’ in mammalian cells.A, Representative recordings of hERG1a, hERG1b and hERG1a/b channels expressed in HEK293 cells are shown. Currents were recorded using the protocol depicted in the inset. Only currents recorded during the ramp are shown. For comparison, currents were normalized to the maximum peak current during the ramp and plotted against the command voltage. The dotted lines indicate the potential where the currents peaked (‘peak potential’) and are also used to indicate the expressed channels. B, Summary data of the variation in ‘peak potential’. For comparison, the peak amplitude was normalized to an estimate of the number of channels (N) and plotted as a function of the ‘peak potential’.
Image published in: Larsen AP and Olesen SP (2010)
Larsen, Olesen. Creative Commons Attribution license
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