Figure 5. Structure and conformational flexibility of the RRM123 complex with EDEN-2U/4U. (a) Model refined from MD simulations showing the arrangement of the three RRMs in the order 2-1-3 from 5′ to 3′ along the RNA substrate. (b) The flexible 35-residue linker between RRM2 and RRM3 allows the C-terminal domain to fold back, as shown schematically. (c) Overlayed structures from the MD ensemble showing changes in orientation about the 8-residue RRM1-RRM2 linker sequence which allows RRM123 to adopt both compact and more extended conformations.
Image published in: Edwards JM et al. (2013)
© The Author(s) 2013. Creative Commons Attribution license
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